Bitter Kola Health Benefit for Glaucoma (Eye Pressure)

An increase in eye pressure can lead to glaucoma, according to a report from The New York Times Health Guide. Researchers at Lagos University Teaching Hospital in Nigeria tested the effectiveness of eye drops that contained 0.5 percent extract of Garcinia kola. The results of their study, published in the January 2010 issue of Middle East African Journal of Opthamology, showed that the opthamolic solution that contained the Garcinia significantly reduced eye pressure when used twice a day.
Bitter Kola Health Benefit for HIV
Bitter kola is a potent antibiotic which could be efficacious in the treatment of HIV and AIDS. A researcher with the Nigeria Natural Medicine Development Agency (NNMDA), Mrs. Chinyere Nwokeke told the News Agency of Nigeria (NAN) that bitter kola could be used in treating opportunistic infections associated with HIV. “Bitter kola is highly recommended in the treatment of HIV and AIDS because of its antibacterial, detoxification, and cleansing properties”, she said.
Mrs Chinyere Nwokeke also said that the chemical Saponin in bitter kola is responsible for its cleansing effect. Saponin is mainly used as tonic for the liver, it enhances the functions of the liver and gall bladder.
Bitter Kola Health Benefit for Cold
Bitter kola is often used to treat the symptoms of colds. It is suggested, in particular, for coughs and sneezing.
Bitter Kola Benefit for Male Fertility (Impotence) 
Garcinia kola, also called bitter kola is sometimes believed to cure impotence. Frequent taking of bitter kola boosts man performance in bed with a woman.
Bitter Kola Benefit for Immune System
Bitter kola is known for its anti-inflammatory and antioxidant properties. It can be used to prevent infections and viruses, especially in relation to the immune system.
Bitter Kola Benefit for Food Poisoning
In many rural areas of Nigeria (and other parts of Africa), when food is suspected to be contaminated by bacteria or someone accidentally eats food poison, traditional healers often recommend the mastication of bitter kola immediately after eating. This usually prevent the development of any infection or poisoning. Herbalists even recommend the seed and the bark of bitter kola should be eaten together in cases where food poisoning is suspected, “it helps to detoxify the system“.
Bitter kola is not only anti-poison, it also has the ability to repel evil spirits according to traditional beliefs. Though it sound superstitious, many (myself included) believe it works and do have spiritual benefits.

Bitter Kola Benefit for treating Ebola

#Update: It is no surprise to me that bitter kola has been reported in Africa to be an effective natural treatment for ebola. It should be common among Africans to think that any immune system boosting food, fruits and nuts may be good for alleviating and treating the symptoms of ebola.

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The amazing health benefits of Bitter Kola (Garcinia Kola)

Bitter kola is a type of nut mostly found in several parts of Nigeria and West-Central Africa as a whole and the tree grows in the (tropical) rain forests. Its biological name is “Garcinia kola” and belongs to the family of “Guittiferal”. Bitter Kola has been identified as a potent antibiotic which could be effective in the treatment of many diseases. The fruit, seeds, nuts and bark of the tropical tree have been used for centuries in traditional medicines to treat many forms of ailments.
Chewing bitter kola relieves coughs, hoarseness, bronchial and throat troubles. Several studies discovered bitter kola to be a remedy for dysentery, osteoarthritis, antidote against poisoning and considered an aphrodisiac.
I hope many Africans both at home and in diaspora will continue to appreciate herbal medicines with little to no side effects compared to pharmaceutical drugs with gazillion known side effects. I have broken down the several health benefits of Bitter Kola (Garcinia kola) for the healing of many common and seasonal ailments:
Bitter Kola Improves Lung Functions
Bitter kola (Garcinia kola) has been used for centuries to treat chest colds in traditional medicine, but research has taken a look and found out why it is effective. A study in the 2009 issue of The Internet Journal of Pulmonary Medicine, performed on mice, reports that Garcinia kola improved respiratory function after 28 days of use of a Garcinia extract. Written by Simon Adekunle of the Ekiti State University in Nigeria, the study shows that Garcinia kola works by dilating the alveolar ducts and sacs in the lungs by improving the strength of the fibers in the lung tissue. Bitter kola’s beneficial lung properties are attributed to its high antioxidant content.
Bitter Kola Health Benefit for Malaria
Considerable experimental studies found the chemical constituents in bitter kola have anti-malaria properties. That aside, traditional healers have for many years prescribed bitter kola for the treatment of malaria infections. Researchers who reported that bitter kola had anti-malaria effect in the 2010 issue of Journal of Medicinal Plants Research, from a survey of plants used by traditional healers in the Democratic Republic of Congo, attributed this to its quinones content.
Further more, kolaviron, the powerful chemical compound found in bitter kola, was reportedly tested on a malaria parasite and found to inhibit malarial activity.

“We extracted its chemical constituents, which is called Kolaviron and when it was tested on malaria parasite, we found it had significant anti-malarial activity,” says Professor Olusegun Ademowo, a researcher at the Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, South West of Nigeria.
“What we are now trying to find out is the right dosage of its extract that would be required in treating malaria. Also, we are looking at what other effects its use will have on the human cells. But at the moment it is in the preliminary stage.”

In 1999, a group of researchers in Kinshasa, Congo, attested to why people should consider feeding more on bitter kola to ward off malaria. Under laboratory conditions, they found extracts from bark, stem and seed of bitter kola tree inhibit the growth of malaria parasite (Plasmodium falciparum) by at least 60% at a low concentration of 6 mg/ml.
Bitter Kola Health Benefit for Osteoarthritis
Osteoarthritis is the most common form of arthritis, characterized by pain, inflammation and limited movement in the joints, according to the National Institutes of Health. Causes of osteoarthritis can include joint injury, obesity and aging. Since many arthritis sufferers prefer natural herbal medicines to other pain relievers and medications, researchers at Obafemi Awolowo University in Nigeria tested the effects of Garcinia kola against arthritis symptoms. The results of the study, written by Olayinka O. Adegbehingbe and published in the July 2008 issue of the Journal of Orthopaedic Surgery and Research, conclude that Garcinia kola significantly reduced inflammation and pain and increased joint movement in subjects that had osteoarthritis symptoms. It is believed that Garcinia kola works well as a result of its antioxidant properties.
Garcinia kola appeared to have clinically significant analgesic/anti-inflammatory effects in knee osteoarthritis patients. Garcinia kola is a potential osteoarthritis disease activity modifier with good mid term outcome; Olayinka O Adegbehingbe, Saburi A Adesanya, Thomas O Idowu, Oluwakemi C Okimi, Oyesiku A Oyelami and Ezekiel O Iwalewa discovered in their study on the Clinical effects of Garcinia kola in knee osteoarthritis.
The side effects reported from the Garcinia kola use in this study were “weight loss”, “increase in sex drive” and “extended sleep” which many considered helpful to meet their individual and marital demands.
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EVERY PART OF BITTER LEAF IS SWEET

It will interest you to know that every part of the plant is useful: stem, leaves, and root. This kind of leaf is very familiar to some people but others may not have any idea about this wonder leaf. Bitter-leaf can grow anywhere unlike other leaves that only grow in certain places and temperature. These leaves flourishes anywhere they grow. They add beauty to all places where they are present. The most distinctive characteristic of this plant is its bitterness. Every part of this plant is bitter starting from the leaves to its roots. The bitterness of this plant is actually good for the body. It has a lot of health benefits to people. The plant can remind people that life is not always sweet; it takes to taste bitterness before you can achieve sweetness.
• This plant is very useful in toning the vital organs of the body especially the liver and the kidney.
• Bitter-leaf can be very helpful in maintaining the livers optimum health to release bile acid every time people eat fatty foods.
• The liver should be well taken care of by using bitter-leaf. Once the liver is been damage it can’t be restored into its normal function. People with liver problems can boil a bitter-leaf and drink a glass of it every day. Bitter-leaf is a natural herb that is useful in taking care of the kidney and the liver.
• Diabetic patient can also use bitter-leaf as one of their medication to prevent high sugar level in the blood. It will not only lower the sugar level in the blood but also repair impaired pancreas.
• Bitter leaf is an important ingredient to fight malaria. When the raw leaves are plucked, they are washed before being squeezed to extract the juice. Drinking the juice alone is an antidote for malaria, The bitter leaf contains vernodalin, venomygdin and saponin which is anti-bacteria and anti-parasitic.
• Bitter leaf when taken in any form prevents rheumatism, indigestion, scurvy and detoxifies the blood.
• Consuming bitter leaf may combat breast cancer cell growth, according to the February 2004 "Experimental Biology and Medicine." In a test tube study of human breast cancer cells, scientists from Jackson State University found that bitter leaf inhibited the growth and proliferation of breast cancer cells. • Where there is no medical help, blood oozing from fresh wound can be stopped by squeezing fresh, green bitter leaves and dropping it on the wound.
• The undiluted extract of bitter leaf is an important cure for Ring worm, eczema and rashes by applying to the affected part of the body.
• Bitter leaf therefore belongs to the class of therapies obtained without the use of drugs.
• Bitter leaf stem can be used as chewing stick
• Apart from its healing potencies, it is also a sure ingredient for making delicious soup.
THE RIGHT WAY TO TAKE BITTER LEAF:
Bitter leaf should always be taken raw and fresh as an alternative health remedies. Boiling or cooking reduces the potency of the leaf. Its bitterness must not be squeezed out before eating; otherwise what will be left is mere chaff with little or no medicinal value. Remember always that raw vegetables are better than cooked ones and half-cooked vegetables are better than over-cooked ones. Keep to nature and live healthy
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THE HEALTH BENEFIT OF BITTER LEAF

It is known by everybody, it grows every where and it is a homely plant. The igbo calls it onugbo, the Yoruba calls it ewuro and the hausa calls it shiwaka. Bitterleaf mostly is esed mostly as a vegetable in igbo land while the Yoruba use it more as a medicine. The fact is that bitter herbs are good for the body. Bitter herbs helps to tone the vital organs of the body, especially the largest organ of the body. Bitter leaves should always be taken fresh. Nigerians eat a lot of bitterleaf, but they often squeeze out the bitterness from the leaves before eating it. What is left then, is mere chaff, with little or no medicinal value. The following are some of the uses of bitter leaf.


 1. STOMACH ACHE 


2. SKIN INFECTION  


For skin infections such as ringworm, itching, rashes and eczema, the pure, undiluted extract of bitter leaf is excellent. Simply apply it to the affected part daily.
3. DIABETES
4. LOSS OF MEMORY
5. PROSTATE CANCER
6. GENERAL WEAKNESS
7. STROKE
8. PNEUMONIA
9. INSOMIA
10. ARTHRITIS
To mention a few. If you want directions as to how to use bitter leaf for treatment of the diseases mentioned above, please don’t hesitate contact us +2348068808564

The Wonders of Bitter Kola

Bitter kola is another type of kola found in Igbo land of Nigeria. Its biological name is Garcinia kola. Like the kola nut it is produced from a big tree. Unlike the kola nut it is monocotyledon. Although it is eaten widely for different purposes it has nothing to do with the tradition of any known ethnic group. It is medicinal as well as has some aspect of spiritual healing factors attached to it. Although modern sciences could try to disapprove of the belief but the issue is that "It works" whether you belief or not. I am glad to proclaim that my friends from different geographical areas who had in the past argued the possibilities of what I claimed bitter kola could do are now addicts in bitter kola usage. One general remark is that bitter kola is an Anti-Biotic. It can be eaten at anytime and again no side effects under normal condition. It is one of those medicines that have no over dose.
To spiritualists and knowledge seekers if you want to know what bitter kola could do find out we offer subscription which gives you the opportunity to buy and have instruction on what it does and how to use it.
Medicinally any body can eat as many as bitter kola as he or she prefers to consume by pilling off the outer coating of bitter kola but be mindful that as the name sounds it is really bitter. However if you can have fun eating bitter kola
you have the chances of not contacting or suffer from common cough syndromes, sour or mouth odor, stomach upset and tooth ache. If you are interested in healthy

soluation

                                                DESEASES

                                                

1. ASTHMA

Asthma is a serious disease that affects breathing. It is a disease of the chest that affects respiration. When a person has asthma, the breathing pipe inside the chest will be contracting and relating. This will give pain and discomfort to breathing. Asthma is a disease that suddenly makes the sufferer to fight for breath wheezing and coughing.


          

2. MALARIA

Malaria is an infection of the bipod that causes chill and high fever. It is spread by mosquitoes by the deposition of malaria parasite in the blood of an infected person. These mosquitoes are present in almost all the countries in the tropics and sub-tropics Including Nigeria. 

3. BOWEL MOVEMENT (CONSTIPATION)

HERBAL REMEDIES - ALOE VERA

One of the greatest healing agencies we have among herbs. Works wonderfully in cleaning out the colon. Gives regular bowel movement Aloe works well on any kinds of sore on the outside of the body. Excellent remedy for piles and hemorrhoid.

4. MEASLES, SMALL POX AND CHICKEN POX

Rub natural pure undiluted honey on the affected part of the body. Because of the Osmotic pressure on human body, honey is capable of extracting pathogens from rashes of measles, small pox and chicken pox. The rashes soon dry up while pure formation is impeded.


 formation is impeded.

5. WORMS EXPELLER

Crush pawpaw seeds, add pawpaw juice and honey and take as frequent as possible till your condition improves.

6. HEART RELATED DISEASE.

(People suffering from heart Attack)

Cardiac Arrest.

Grind 10 bulbs of garlic and 10 bulbs of onions mix thoroughly with 3 litre of natural pure honey. Garlic and onion contains lecithin which can get rid of accumulation of (cholesterol) from the system. Studies have shown that people who regularly consume relatively large amount of Garlic and onions have lower cholesterol level than those who do not. Intact experts have warned that if a healthy heart is to maintained one or two average size cloves of garlic is compulsory daily. 


7. INSTANT ACHE RELIEVER FOR HEADACHE.


 8. DIABETES MELLITUS  

9. HYPERTENSION (HIGH BLOOD PRESSURE)

Hypertension encephatopathy is one of the complications of high blood pressure that if not treated could lead to unexpected death. It could start like loss of memory, sleeplessness, tiredness, a choking sensation with severe chest pain are signs of Hypertension.

10. SEVERE COUGH

BITTER KOLA (Garcinia Kola) Bitter Kola is good for cough, bronchial and throat problem. 

 11. JAUNDICE IN CHILDREN  

12. THROAT PROBLEM

(GINGER)

For healthy living ginger serves as a herbs spice and flavour. For cold, chest Problem, catarrh, Bronchitis, throat problem or use as antipyretic in case of fever.

 13. OBESITY (LOSE THE WEIGHT

14. LOW SPERM COUNT

When a man engages in unprotected sexual activities with a woman, he releases into the woman a chalky white substance known as sperm. Each ejaculation of a man during sex contains at least 20 million sperm cells/ml for pregnancy to be achieved. Anything lower than 20 million sperm cell may cause infertility in man that is the man unable to pregnant his wife. This defect is known Medically as Oligospermia.


 15. BLOOD TONIC AND BLOOD PURIFIER

 16. HEART, LIVER AND LUNG DISEASE  


17. PIMPLES  


18. HAIR BREAKAGE

 19. STOMACH ULCER 


20. WEAKNESS OF ERECTION OF PENIS 


21. HEMORRHAGE IN WOMEN  


22. THE IMPORTANCE OF GARLIC (ALLIUM SALIVUM)  



23. RHEUMATISM & ATHRITIS  


24. PROTRUDING PILE  


25. FIBROID  



26. GOITER


 27. INSOMNIA (SLEEPLESSNESS)


 28. ECZEMA 


29. LOW BLOOD PRESSURE 



30. CLEANING OUT THE COLON  


31. TO CURB YOUR APPETITE  


32. LIVER PURIFYING AGENT. 


33. SWOLLEN AND BLEEDING GUMS 


34. STOPPING VOMITING  



35. BLADDER INFECTIONS


 36. INFLAMMATIONS 


37. DIGESTIVE STIMULANT. 


38. BROKEN AND WEAK BONE 



39. DETOXIFICATION OF POISON IN THE LIVER.

40. STONE IN THE KIDNEY.

PARSLEY LEAF 

 41. MENSTRUAL DISORDER.


 42. NERVOURS HEART DISORDERS.  


43. EXECUTIVES STRESS  



44. STROKE & EPILEPSY  


45. HYPERTROPHY OF THE PROSTATE GLAND. 

46. ANEMIA

Anemia is a common blood condition in which there is a shortage of either erythrocytes or haemoglobin or both. Anemia is a very common disorder far more common than many people realize. A person become anemic for two reasons either he has few' red cells circulating in his blood stream or bone marrow or else there is not enough haemoglobin in the cell or an excessive loss of blood due to hemorrhage or restructure of the cells.

47. SICKLECELL ANAEMIA/LEUKAEMIA/IMPURE BLOOD

It is a fatal condition, sometimes termed "cancer of the blood" in which there is an abnormal increase in the number of leukocytes. Symptoms of impure blood manifest when there is premature aging, wrinkles, poor skin texture, poor eye sight, loss of hair, pains in various parts of the body, infertility and low potency. Sickling is the result of some abnormality in the haemoglobin within the red cells

 48. BLOOD CLEASING AND BLOOD BUILDING

49. TO ELIMINATE THE TOXIC RESIDUES OF ALCOHOL

HANGOVER

 50. CATARACTS

 51. CHOLERA
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Bitter kola’s many health benefits

Bitter Kola, Garcinia kola, used extensively in West Africa as a social beverage and offered to guests as ‘Kola’ in many of Nigeria’s cultural settings, is valued also for its medicinal properties. It is used in traditional medicine for the treatment of Laryngitis, general inflammation, bronchitis, viral infections and diabetes as well as a rejuvenating agent, adaptogen and general antidote. Scientists at our laboratories have performed extensive research and written many books on this wonder plant called ‘Garcinia’. Researchers have identified bitter kola as a potential antibacterial, anti-inflammatory, anti-diabetic and a potential detoxifying agent.
Bitter kola is a food supplement and anti-infective agent in the management of cold, bronchitis, and it reduces congestion of the upper respiratory tract.
Because some people do not like to chew Bitter kola, yet want to experience its potency in some of the above, at Bioresource Development Group (BDG) has come up with a formulation, called Garcinia-IHP.
Garcinia-IHP is a scientifically processed garcinia kola which retains all the goodness of bitter kola in capsules, with the potency and effectiveness guaranteed.
 Major indications
Cold remedy
Very effective in managing symptoms of cold and sore throat, pains, cough, nasal congestion and helps coagulate phlegm.
Antimicrobial
It is used in many tropical countries to fight infectious diseases. It is effective for managing pains, bacteria and viruses.
Detoxification
Garcinia has a cleansing effect on the liver, gall bladder and the entire body system.  It reduces the absorption of poison.
 Anti-inflammatory activity
Kolaviron is a deflated ethanol extract from the seeds of garcinia kola, which studies have shown to have analgesic and anti-inflammatory properties.
Other health benefits
Immunity:The anti-inflammatory and antioxidant property makes the body resistant to infections. It is used to prevent infections especially in people with immune system.
Libido enhancement:Impotence is restored by increasing blood supply to the core area in men who have hardening of the arteries. Bitter kola is the number one sexual performance medicine for men. Few natural products can match the sexual benefits of bitter kola.
Hangover:It prevents the alcoholic induced hangover and improving lung function.
Improving lung function: Garcinia kola has been used for centuries to treat chest colds in traditional medicine, but research has taken a look and found out why it is effective. A study in the 2008 issue of The Internet Journal of Pulmonary Medicine, performed on mice, reports that Garcinia Kola works by dilating the alveolar duct and sacs in the lungs by improving the strength of the fibres in the lungs tissue. Garcinia Kola’s beneficial attributed to its high antioxidant content.
Reduction of eye pressure:An increase in eye pressure can lead to glaucoma, according to a report from The New York Times Health Guide. Researchers at Lagos University Teaching Hospital (LUTH), Idi Araba, Lagos, tested the effectiveness of eye drops that contained 0.5 percent extract of Garcinia Kola. The results of their study, published in the January 2010 issue of Middle East African Journal of the Opthamology showed that the opthamolic solution that contained the Garcinia significantly reduced eye pressure when used twice a day.
Relieve arthritis: Osteoarthritis is the most common form of arthritis, characterised by pain, inflammation and limited movement in the joints, according to the National Institutes of Health. Causes of osteoarthritis can include joint injury, obesity and aging. Since many arthritis sufferers prefer natural herbal medicines to other pain relievers and medications, researchers at Obafemo Awolowo University in Nigeria tested the effects of Garcinia kola against arthritis symptoms. The result of the study, written by Olayinka O. Adegbehingbe and published in the July 2008 issue of the Journal of Orthopaedic Surgery and Research, conclude that Garcinia kola significantly reduced inflammation and pain and increased joint movement in subjects that had osteoarthritis symptoms. It is believed that Garcinia Kola works well as a result of its antioxidant properties. What the study termed as the “side effects” of Garcinia Kola were “weight loss”, “increase in sex drive” and “extended sleep” which many considered helpful to meet their individual and marital demands.
Medical significance: Garcinia kola is used to fight infectious diseases. It has shown to possess anti-inflammatory, antimicrobial and antiviral properties.
Blood glucose lowering: The folk use of bitter kola in the management of elevated blood sugar has been validated by several laboratory studies. Garcinia-IHP is beneficial as a food supplement for diabetics.
Weight loss: Bitter kola has been shown to be a natural hunger suppressant and also increases the urge to drink more water.
How to use bitter kola: It should be eaten by removing outer brown coated skin. As the name implies it is very bitter to eat, hence, Garcinia-IHP is encapsulated Garcinia kola, so if you cannot handle the bitter taste of the raw seeds, you can still enjoy the benefits that it offers to your health.
Antioxidant property: Bitter kola contains kolaviron, mixture of bioflavonoids,  benzophenones and chromanols which are responsible for its strong antioxidant activities. An evaluation of the antioxidant properties of garcinoic acid (structurally similar to vitamin E) and its congeners showed that it has a stronger antioxidant activity than vitamin E.
Bitter kola as an adaptogen: It is intriguing that bioflavonoids of Garcina kola are capable of modulating almost any physiological anomaly. The answer perhaps lies in the role of flavonoids in the evolutionary course of human beings. Humans, over many millennia, have adapted to a diet, which is favourable for the survival and the flavonoid-like structures, were part of that primordialphysiological scheme.
If you take Garcinoa-IHP and experience diarrhea, hives, irregular heartbeat other signs of allergic reaction, discontinue use immediately and seek medical attention.

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Blood Pressure Reducing Effect of Bitter Kola

active ingredients. The seeds are used in Nigerian

traditional medicine, for therapy of broad spectrum of

ailments such as in dysentery and diarrhoea

diseases

(Braid 1992). There are claims, that traditional

medicine practitioners use

Garcinia kola

seeds for the

treatment of hypertension. There are also reports that

Garcinial kola

, reduce glutation concentration, and also

inhibits prostaglandin synthes

is (Makander 1986).

Garcinia kola

has a spamolytic effect on

gastronintestinal smooth muscle (Briad 1989). It

relaxes the smooth muscles of the uterus and

gastrointestinal tract. It has been reported to stimulate

Histamine dependent gastric acid secretion

(Oluwole

et

al

1992). Recently, the antithrombotic activity of GK

has been reported (Olajide 1999) and its antibacterial

effect on respiratory tract pathogens has also been

reported (Akoachere 2002). Elekwa et al 2003 reported

that aqueous extract of GK st

abilized the membranes of

HbAA, HbAS and HbSS human erythrocytes and

reduced blood viscosity. Also GK have been reported

to reduce body weight, reproductive organ weight and

inhibit spermatogenesis in male wistar rats (Naiho

2004).

However, no report has

been sighted on the effect

of

Garcinia kola

on blood pressure, vascular smooth

muscle and cardiac muscles. This work aims at

investigating the effect of

Garcinia kola

ingestion in

rats and its effect on the blood pressure.

MATERIALS AND METHODS

Prepara

tion of Garcinia kola enhanced diets

Garcinia kila

seeds were bought from Uselu

market in Benin City. The seed coat was removed and

the seeds were dried in an oven at a temperature of

80

0

C, these seeds were weighed every 24 hours until a

constant weight w

as obtained. The seeds were then

grounded into powder.

Animal grouping and

experimentation

Fifteen Wister rats obtained from the Faculty of

Science Uniben and kept under normal environmental

conditions were divided into three groups A, B and C.

Groups A

rats had normal rat chow and water libitum

while group B rats had

Garcinia kola

diet (10% w/w)

made by mixing 90g of rat chow and 10g of

Garcinia

kola

. Group C rats had

Garcinia kola

diet (15% w/w)

made by mixing 85g of rat chow and 15g of

Garcinia

kola

.

Both groups had free asses to tap water. Their

blood pressure was monitored weekly for a period of 6

weeks with the aid of a non

-

invasive blood pressure

measuring device (rat

-

tail cuff equipment).

Plant Extraction

100g of GK powder was extracted with 3

00ml of a

2:1 mixture of chloroform and methanol using soxhlet

apparatus. At the end of extraction the extract was

concentrated, and solvent was totally evaporated in a

petri dish and a fine brownish powder was obtained.

Different concentration of crude e

xtract was made by

dissolving a known mass of extract in 10ml of a solvent

made up of 0.5ml of 70% ethanol and 9.5ml of distilled

water.

Rats for this second experiment, were kept under

environmental conditions and at room temperature, and

were fed norma

l rat chow and water ad libitum until

they attained an average of 185g of body weight.

Animal preparation

Rats were anaesthetized with thiopentone sodium

(100mg/kg b.wt), blood pressure (BP) and heart rate

(HR) was measured via a canula placed in the car

otid

artery connected through a force/pressure transducer to

a measuring device (Ugo Basil Italy). Solvent alone

was injected via jugular vein and BP and HR were

recorded, and used as control. Different doses of extract

were then injected and BP were recor

ded. During this

experiment normal saline was periodically infused to

compensate for loss of fluid.

Chemical Analysis

Phytochemical Analysis revealed that extract contains

Flavonoids, Tanins, Saponins, Biflavonoids and Resins.

Statistical Analysis

Stu

dent unpaired t

-

test was used to compare means and

p<0.05 was accepted as being statistically significant.

RESULTS

AND DISCUSSION

Table

1

, shows changes in Systolic Pressure (n=5).

Systolic blood pressure of treated groups reduced

significantly (p<0.05)

in the third week.

Table 2 shows

effect of graded dose of extract on Blood pressure and

heart rate of Wistar rats (n = 10).

Dose range of 1 g/kg

bwt produced a significant (p<0.05) fall in mean

arterial blood pressure and a significant (p<0.05)

increase i

n basal heart rate.

Table 3 shows effect of

cholinergic blockade (ACB) and Histaminergic

blockade (AHB), on blood pressure reducing effect of

Garcinia kola

extract.

The blood pressure lowering effect of several plant

materials have been investigated and d

ocumented, these 

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131 www. ajbrui. net Full length Research Article Blood Pressure Reducing Effect of Bitter Kola

131

www.

ajbrui.

net

Full length Research Article

Blood Pressure Reducing Effect of Bitter Kola

(

Garcinia

kola

,

Heckel

)

in Wistar Rats

Naiho A.O. &

*

Ugwu A.C.

Department of Physiology, Delta State University & University of Benin

ABSTRACT:

In this study the effect

of

Garcinia kola

(GK)

on blood pressure was investigated.

Albino wistar

rats were

divided into three groups

.

Groups A rats had normal rat chow and water ad

-

libitum while groups B and C rats had

Garcinia

kola

diet of 10% w/w and 15% w/w respectively, their

blood pressures were monitored weekly for a period of 6 weeks.

Secondly, inbred wistar rats weighing on the average 185g were anaestezized with thiopentone sodium 100mg/kg body weight

(b.wt) intraperitoneally and prepared for injection and for blood pressu

re measurements on a recording device (Ugo Basile

Itlay).

S

ignificant reduction in blood pressure (P<0.05) was observed in

rats given

G

K

-

enriched diets

,

in the third week. During

preliminary investigations it was observed that 5.0mg/kg b.wt dose of extract

was lethal after 6 minutes, while 3.0mg/kg b.wt

of the extract was tolerated for upwards of four hours. Based on these findings, graded doses of the extract. (0.5

–

3.0mg/kg)

were used and these doses produced statistically significiant (P<0.05) fall in m

ean arterial pressure and also significant

(P<0.05) increase in heart rate. Cholinergic blockade produced no significant attenuation on the effect of extract. However

there was a significant (P<0.05) attenuation to extract effect after Histaminergic blocka

de. This study shows that

Garcinia kola

contains in its alcohol extract, a v

a

soactive substance that has a blood pressure reducing effect.

KEY WORDS:

blood pressure,

Garcinia kola

, Vasoactive, Heart rate

INTRODUCTION

1

These agents usually act through electrical or non

-

electrical pathways. It is known that agents such as

Hypertensive disorders are the m

ost common causes of

adult morbidity and mortality in Africa. Many workers

have discovered many vasoactive substances capable of

reducing blood pressure. These include studies on the

blood pressure lowering ability of some natural plant

materials, such as

extracts of garlic, seed of pawpaw

(carica papaya), calyx of hibiscus and petals of

hibiscus.

Vasoactivie agents are considered to be any

physiologically occurring or exogenously administered

hormonal substance that alters the activity of vascular

smooth

muscle i.e. that cause its contraction, relaxation,

or both. (Bohr et al 1979).

1

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acetylcholine, alters membrane permeability and hence

change the net

diffusion potential, hyperpolarizing the

membrane and bringing about relaxation of vascular

smooth muscles (Nakajima and Hom 1967).

Cholingergic agents, also alters the frequency and other

characteristics of the action potential and these

alterations cause

changes in the mechanical

performance of the portal vein (Von Loh, 1971). The

cyclic AMP pathway is another process by which some

vasodilators bring about relaxation of vascular smooth

muscle supportive of this mechanism and this is

because the fact that

cyclic AMP itself, causes

vasodilatation. Anderson (1992) has presented

extensive evidence that suggest cyclic AMP stimulates

an energy requiring Ca

2+

binding mechanism that leads

to a decreased concentration of sarcoplasmic calcium,

and hence relaxation.

G

arcinia kola, known as

“false” kola, belongs to

the order of guterferae and contains pharmacologicall

Health Benefits Of Zobo Drink

Hibiscus has been proven to reduce blood pressure and cholesterol levels.
It is caffeine-free and has 100 per cent of recommended daily Vitamin C.
Extracts of the flower is alkaline in nature and contains cleansing properties.
It helps to keep the body’s pH balanced, (without white sugar).
The flower has pectin that can make a firm jelly.
The red flower contains antioxidants including flavonoids.
The fresh Hibiscus flower is also rich in riboflavin, vitamin C, niacin, carotene, calcium, and iron, which are all nutritionally necessary.

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